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Metral may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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clinical trial was performed to assess the analgesic efficacy and reported side effects of Metral 100 mg, Metral 50 mg,
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Metral and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Metral and M1, respectively.
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Metral is well absorbed orally with an absolute bioavailability of 75%. Metral has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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This effect may go away if you lie down forawile.
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This is known as physical DEPENDENCE. If you suddenly stop taking Metral , you may experience WITHDRAWAL symptoms including anxiety;
patients receiving Metral had a median gastric fluid pH of 6.4,
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Metral is administered as a racemate and both [-] and [+] forms of both Metral and M1 are detected in the circulation.
This effect may go away if you lie down forawile.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Metral and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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A single i.m. dose of Metral is useful pre-treatment to minimize the risk of acid aspiration during operation,
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