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In an open randomized trial, rectal Sinemet was compared with our standard treatment acetaminophen/codeine suppositories. We expected Sinemet to be equally effective as our current standard but with fewer side effects.
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Nonetheless, Sinemet nearly doubled the interthreshold range at a concentration near 200 ng/mL.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Sinemet and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Sinemet and M1, respectively.
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This indicates that Sinemet slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Sinemet ; it may add to their effects.


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Sinemet may rarely be habit forming. Sinemet should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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Sinemet may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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For Sinemet, the following should be considered:The suitability of Sinemet.
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How does Sinemet work? What will it do for me?Sinemet can cause side effects that may impair your thinking or reactions.
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A single i.m. dose of Sinemet is useful pre-treatment to minimize the risk of acid aspiration during operation,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Sinemet and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Sinemet has been shown to cause harm to the fetus.
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