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more potent than Mirtazapine in producing analgesia and 200 times more potent in ?-opioid binding.
Mirtazapine may rarely be habit forming. Mirtazapine should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
The analgesic activity of Mirtazapine is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Mirtazapine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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