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Promethazine is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Tell your doctor or dentist that you take Promethazine before you receive any medical or dental care, emergency care, or surgery.
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These mechanisms may contribute independently to the overall analgesic profile of Promethazine.
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causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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You may not be able to take Promethazine, or you may require a dosage adjustment,
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The analgesic activity of Promethazine is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Promethazine was not mutagenic in the following assays:
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Promethazine has not been shown to cause histamine release. At therapeutic doses, Promethazine has no effect on heart rate, left-ventricular function or cardiac index.
Talk with your doctor if Promethazine stops working well. Do not take more than prescribed.Some people who use Promethazine for a long time without a break may develop a physical need to continue taking it.
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For Promethazine, the following should be considered:The suitability of Promethazine suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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The effects of Promethazine are similar to those of narcotic analgesics. Although Promethazine is not classified as a narcotic, it may become habit-forming,
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