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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Sinequan is rapidly and almost completely absorbed after oral administration.
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Sinequan was being used with selective serotonin reuptake inhibitors (10 cases),
1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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Sinequan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Sinequan is a centrally acting synthetic opioid analgesic.
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In general, both enantiomers of Sinequan and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Use Sinequan with caution in the ELDERLY; they may be more sensitive to its effects.Sinequan should not be used in CHILDREN younger than 16 years old;
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Sinequan has not been shown to cause histamine release. At therapeutic doses, Sinequan has no effect on heart rate, left-ventricular function or cardiac index.
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Breast-feeding�Sinequan passes into breast milk and may cause unwanted effects in nursing babies.
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The relative risk of experiencing an episode of nausea under treatment,
Sinequan increases the risk of CNS and respiratory depression in these patients.
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