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The effects of Sominex and its metabolite mono-O-demethyl-Sominex,
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Sominex may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Sominex has been shown to cause harm to the fetus.
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There were no other significant respiratory diffences.
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When used for long periods of time or at high doses,
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This indicates that Sominex slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Sominex has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Sominex has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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Sominex has both opioid and monoaminergic agonist actions.
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Sominex may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Taking Sominex together with medicines that are used during surgery or dental,

It is slightly soluble in water and freely soluble in alcohol,
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Sominex has not been shown to cause histamine release. At therapeutic doses, Sominex has no effect on heart rate, left-ventricular function or cardiac index.
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Sominex has not been shown to cause histamine release. At therapeutic doses, Sominex has no effect on heart rate, left-ventricular function or cardiac index.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Sominex and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Sominex is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Check the label on the medicine for exact dosing instructions.Sominex may cause drowsiness and dizziness.
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