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Racemic Emsam is rapidly and almost completely absorbed after oral administration.
Emsam may rarely be habit forming. Emsam should be avoided in patients with a history.
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risk of discontinuation due to adverse events associated with higher initial doses,
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The analgesic activity of Emsam is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Other withdrawal symptoms include unnecessary restlessness of the legs,
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No effects on fertility were observed for Emsam at oral dose levels up to 50 mg/kg,
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Emsam is well absorbed orally with an absolute bioavailability of 75%. Emsam has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
Do not stop using this medication suddenly without first talking to your doctor.
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Check with your health care provider before you start, stop, or change the dose of any medicine.Use Emsam as directed by your doctor.
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whereas Emsam 50 mg was statistically superior to placebo onlyfor remecation time.
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the rates of withdrawals due to adverse events appeared to be higher in the Emsam groups.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Emsam and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Emsam and M1, respectively.
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Although Emsam is known to exhibit a local anaesthetic effect, how Emsam exerts this effect is not understood fully.
Talk with your doctor if Emsam stops working well. Do not take more than prescribed.Some people who use Emsam for a long time without a break may develop a physical need to continue taking it.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
In vitro studies indicate that Emsam is unlikely to inhibit,
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Emsam may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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The analgesic activity of Emsam is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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